EXECUTIVE SUMMARY
Hyro is a conversational AI platform built specifically for healthcare -- not adapted from a generic enterprise chatbot. It automates inbound patient phone and chat interactions: appointment scheduling, prescription refills, FAQs, wayfinding, and claim status inquiries. The pitch is call center deflection at scale. The results from published case studies are real, and the $95M in total funding (most recently $45M in October 2025) reflects genuine commercial traction. The critical question for any RCM leader is not whether Hyro works -- it does, in the right environments -- but whether your organization has the Epic integration depth to unlock the ROI tier worth buying into.
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Company Profile
Founded: 2018
HQ: New York, NY (founded in Israel)
Funding: $95M total -- $20M Series A (2022), $30M Series B (2024), $45M growth round (October 2025)
Investors: Healthier Capital (lead, 2025), Norwest, Define Ventures, Bon Secours Mercy Health (strategic), ServiceNow Ventures
Stage: Growth -- the October 2025 round doubled the company's valuation in 10 months
Ownership: Private
Key product: Adaptive Communications Platform (voice + chat AI agents)
Epic Certified: Yes
The Bon Secours Mercy Health investment is notable. When a major health system that is also a customer writes a check into your growth round, that is a signal the relationship goes beyond a pilot.
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What Hyro Actually Does
Hyro is a patient-facing AI layer that sits in front of your call center and EHR. It handles the volume that should not require a human: scheduling appointments, checking on prescription refills, answering location and hours questions, and routing complex calls to the right department.
The platform connects directly into Epic (and Salesforce Health Cloud, Genesys, and Cisco) to take real action -- not just collect information and hand off to staff. That is the distinction that matters. A Hyro agent that can actually schedule an appointment inside Epic without a human in the loop is operationally different from a chatbot that collects intent and escalates.
Core use cases:
- Appointment scheduling and rescheduling (voice and chat)
- After-hours call handling (no hold times, no after-hours voicemail)
- Prescription refill routing
- Pre-visit FAQ (insurance, location, prep instructions)
- Claim status inquiries (basic)
- Inbound call triage and routing
Where Hyro is not the right tool:
- Complex clinical triage (needs licensed clinical judgment, not AI)
- Prior authorization appeals and dispute management (too nuanced)
- Billing dispute resolution (legal and compliance sensitivity)
- Organizations without Epic -- integration depth depends heavily on your EHR
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Real Results From Real Customers
Hyro publishes case studies with specific numbers. These are worth reading because they are specific:
Prisma Health: $300,000 in first-year value. 7,500+ automated conversations per month. 80% patient satisfaction score on AI-handled interactions.
Overlake Hospital: 50% reduction in routine call volume. Deployed via voice agents for inbound scheduling and FAQ.
Intermountain Health: 79% of chat interactions resolved end-to-end without human involvement. 85% reduction in call abandonment rate. 79% improvement in speed-to-answer.
Tampa General Hospital: Voice agent deployment for high-volume scheduling center.
The pattern across these customers: large health systems with high inbound call volume and Epic as their primary EHR. That is the ideal buyer profile.
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THE ROI MATH
Hyro released its 2026 Healthcare AI Agent Benchmark Report in January, surveying 387 director-level and above healthcare leaders. The key finding:
Among health systems using advanced, configurable EHR integrations, 82% report annual ROI exceeding $500,000. Only 18% of organizations on standard FHIR connections hit that threshold.
At the $1M+ tier: 15% of advanced integration users exceed $1M annually versus 1% of standard integration users.
Average annual ROI across all respondents: $586,000.
The implication for buyers: the ROI gap between deep Epic integration and surface-level FHIR connectivity is not incremental -- it is 4-5x. The platform is not the variable. The integration architecture is.
94% of respondents say agentic AI is now a critical part of patient-facing operations. Only 59% have standardized processes to track performance. That measurement gap is where most organizations are leaving money on the table.
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PRICING
Hyro does not publish pricing. Enterprise SaaS for health systems at this scale typically runs in the $150,000-$400,000 per year range depending on call volume, number of channels (voice vs. chat vs. both), and integration depth. You will go through a sales process.
If you are a health system with fewer than 200,000 annual inbound calls, the ROI math may not pencil. This platform is built for volume.
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Competitive Positioning
The main alternatives in the patient-facing AI space are Nuance (now Microsoft) DAX and Dragon Ambient eXperience, Artera (formerly Relatient), and Orbita.
Nuance is the 800-pound gorilla, but it is primarily a clinical documentation tool, not a patient access platform. Artera focuses on outbound patient communication (reminders, recalls). Orbita targets virtual agents for health systems but with less depth on EHR write-back.
Hyro's differentiation is the depth of Epic integration -- specifically, agents that can complete transactions inside Epic rather than routing to a human to complete them. If you are evaluating this category, that is the question to ask every vendor: can your agent write back to Epic, or does it hand off?
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What Rcm Leaders Should Know
Hyro lives in patient access, not in the billing office. But what happens at the front end directly affects downstream RCM:
- No-show rates drop when patients can reschedule by phone or chat at 10 PM without waiting on hold. Lower no-shows mean better slot utilization and less revenue leakage from appointment gaps.
- Insurance verification timing improves when scheduling AI captures insurance information at booking and routes it to pre-authorization workflows before the appointment.
- Denial rates have an access component. Wrong insurance captured at scheduling, or eligibility not verified because the patient called after hours, creates downstream denial exposure. A 24/7 capable scheduling agent closes that gap.
The case for Hyro to a CFO or VP of Revenue Cycle is not "buy an AI chatbot." It is: front-end access failures create back-end revenue problems. This platform fixes the front end.
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BOTTOM LINE
Hyro is a legitimate platform with real customer results and meaningful backing. The Intermountain Health numbers -- 79% end-to-end resolution, 85% call abandonment reduction -- are not marketing fluff; they are published outcomes from a named enterprise customer.
The ceiling on ROI is tied directly to integration depth. If you are on Epic and willing to invest in configurable integration rather than standard FHIR, the $586K average annual ROI is achievable. If you are not on Epic or are planning a surface-level deployment, the outcomes will be materially lower.
The right buyer profile: large health system, Epic EHR, high inbound call volume (200K+ annually), and a call center cost structure that makes $300K-$600K in savings meaningful.
If that is your organization, Hyro is worth a serious evaluation. If it is not, there are lighter-weight alternatives that will fit better without the enterprise implementation complexity.